* Putin, 68, spoke to NBC News on Friday ahead of his meeting with Joe Biden
* Biden meets Russia's leader - who he has known for decades - on Wednesday
* In March Biden said that Putin was 'a killer' - remarks that made Putin chuckle
* The Russian president said that he hoped to have a stable relationship with U.S.
* He described Trump as 'colorful', 'talented' and 'extraordinary'
* Putin said questions about deaths of Russian dissidents were 'verbal indigestion'
* He said reports of him backing Iran's satellite program were 'nonsense garbage'
* Biden has previously said he confronted Putin and told him he had no soul
Vladimir Putin burst into laugher when asked if he is a killer - and heaped praise on Donald Trump, before branding Joe Biden a career politician.
The Russian president guffawed when NBC correspondent Keir Simmons asked him: 'Mr President, are you a killer?' during an interview broadcast Friday night.
He avoided directly answering, instead replying: 'Over my tenure, I've gotten used to attacks from all kinds of angles and from all kinds of areas under all kinds of pretext and reasons and of different caliber and fierceness, and none of it surprises me.'
'So as far as harsh rhetoric I think this is an overall expression of US culture. Of course in Hollywood, there are some underlying deep things in Hollywood - macho, which can be treated as cinematic art. But that's part of US political culture, it's considered normal. By the way, not here, it is not considered normal here.'
Putin was speaking in Moscow ahead of his June 16 meeting with President Biden in Geneva. Biden said earlier this year he believed his Russian counterpart was a killer, while Donald Trump did not give a direct answer when asked the same question during his time in office.
Simmons pushed Putin further on the matter, saying: 'I don't think I heard you answer the question, a direct question, Mr President.'
Putin - who appeared to bristle at being pushed further, said: 'I did answer, I did answer. I'll add if you let me. I've heard dozens of such accusations, especially a period of some great events during our counter terrorism events in northern caucuses.
'When that happens, I'm always guided by the interests of the Russian people. The Russian state. In sentience of terms of who calls somebody who, in terms of labels, this is not something I worry about in the least.'
Simmons then reeled off a list of names of Putin critics who died in murky circumstances.
They included Alexander Litvinenko, killed by radiation poisoning in London in 2006, and Mikhail Lesin, who was murdered in Washington DC in 2015.
Putin, a former KGB lieutenant colonel, said: 'Look, you know, I don't want to come across as being rude, but this looks like some kind of indigestion except that it's verbal indigestion. You've mentioned many individuals who indeed suffered and perished at different points in time for various reasons, at the hands of different individuals.'
Speaking of Lesin, he added: 'I regret to this day he is not with us - we found some of the other criminals who committed these crimes. They are in prison.
Meanwhile, Putin used the same interview to hail Donald Trump, while offering more lukewarm praise - and a backhanded compliment - when asked to share his thoughts on Joe Biden.
He told Simons: 'Well even now, I believe that former U.S. president Mr Trump is an extraordinary individual, talented individual, otherwise he would not have become U.S. president.
'He is a colorful individual. You may like him or not.
'And, but he didn't come from the U.S. establishment. He had not been part of big-time politics before, and some like it, some don't like it but that is a fact.'
On the current president, Putin said: '(Biden) is radically different from Trump because President Biden is a career man. He has spent virtually his entire adulthood in politics.'
Putin added: 'That's a different kind of person, and it is my great hope that, yes, there are some advantages, some disadvantages, but there will not be any impulse-based movements on behalf of the sitting U.S. president.'
Trump was dogged by accusations of his being too cozy to Russia, and in awe of their strongman leader.
Putin and Biden will meet in Geneva on Wednesday.
The White House has said Biden will bring up ransomware attacks emanating from Russia, Moscow's aggression against Ukraine, the jailing of dissidents and other issues that have irritated the relationship.
Last year Biden told his biographer, Evan Osnos, about meeting Putin in the Kremlin in 2011.
'I said, 'Mr Prime Minister, I'm looking into your eyes, and I don't think you have a soul,'' Biden recalled.
'And he looked back at me, and he smiled, and he said, 'We understand one another.' This is who this guy is!'
In March, Biden described Putin as 'a killer'.
'This is not something I worry about in the least,' Putin said.
'Over my tenure, I've gotten used to attacks from all kinds of angles and from all kinds of areas under all kinds of pretext and reasons and of different caliber and fierceness, and none of it surprises me.'
He dismissed the 'killer' label as 'Hollywood macho.'
Pressed further by Simmons, who mentioned by name some of the Putin opponents who have been killed in recent years, the Russian leader bristled.
Biden, at the start of an eight-day visit to Europe this week, said: 'We're not seeking conflict with Russia.'
'We want a stable and predictable relationship.
'But I've been clear: The United States will respond in a robust and meaningful way if the Russian government engages in harmful activities.'
On the issue of recent ransomware attacks that the United States has traced to Russia, Putin denied any knowledge of the hackings and called on Biden to reach an agreement with him on cyberspace, NBC News said.
Putin also dismissed a report in the Washington Post this week that Russia was preparing to supply Iran with an advanced satellite that would enable it to track potential military targets across the Middle East.
'It's just fake news. At the very least, I don't know anything about this kind of thing,' Putin said.