Pfizer gives first doses of experimental vaccine to 'young and healthy' American

[cadence4u]

Pfizer gives first doses of experimental vaccine to 'young and healthy' Americans - and promises 20 million doses by the end of the year

* Pfizer announced Tuesday that the first volunteers gotten doses of its experimental coronavirus vaccines
* 360 healthy Americans will be recruited, with various doses going first to young adults ages 18-55, and later to seniors
* If proven safe, Pfizer said it could make 20 million doses by the end of the year

Pfizer has begun dosing Americans with its experimental coronavirus vaccines for its clinical trial in collaboration with BioNTech SE, the pharmaceutical giant announced Tuesday.

The US drugmaker and German partner said if the vaccine proves to be safe and effective in trials, it could potentially be ready for wide US distribution by the end of the year, shaving several years off the typical vaccine development timeline.

The vaccine, which uses messenger RNA (mRNA) technology, has the potential to be among the first vaccines against the virus that has infected more than 1 million people in the United States and killed some 68,000.

Pfizer joined the race to make a coronavirus vaccine late, but hopes that with its trial in 360 healthy volunteers, it can speed ahead and have more than 20 million doses ready by year-end - if the shot proves safe. 

There are currently no approved treatments or vaccines for the new coronavirus, though some drugs are being used on patients under an emergency use authorization.

The US study is part of a broader, global program already underway in Germany, where BioNTech is based. Dosing there began last month.

Moderna Inc is using similar technology for its vaccine being developed along with the US government. Phase I testing of that vaccine candidate has also begun, with mid-stage trials planned in the current quarter.

Pfizer said last week it hopes to receive emergency authorization from the US Food and Drug Administration (FDA) as early as October, and could distribute up to 20 million doses by the end of 2020, with an eye toward producing hundreds of millions of doses next year.

'Even going from a few million to 20 million will allow you to protect the epicenters of the virus, and then drive out the virus from our society as we ramp up to hundreds of millions,' Pfizer research chief Mikael Dolsten told Reuters in an interview.

Using synthetic mRNA technology can enable the vaccine to be developed and manufactured more quickly than traditional vaccines, the companies said.

Pfizer said last week it expects to make safety data on the vaccine available by late May.

The trial will initially aim to test different dosing regimens of four potential vaccine candidates on around 360 healthy volunteers divided into a younger cohort and a group of seniors.

The trial will expand to more subjects after researchers determine which compounds and dosing regimens are most effective, said Kirsten Lyke, a director at the University of Maryland's Center for Vaccine Development and Global Health, which is participating in the trial.

Doses have already been administered to some volunteers at NYU Grossman School of Medicine and the University of Maryland School of Medicine.

Pfizer plans to expand the trial to sites across the United States in early July, and may ultimately enroll more than 8,000 participants, a company spokeswoman said.

If successful, the U.S. clinical trial would be one of the fastest ever progressions of a vaccine from early stage studies to regulatory approval, compressing a development process that often takes as much as a decade to just over nine months.

'This is the equivalent of doing phases one, two and three of a typical clinical trial but all compressed into the May through October time frame,' Lyke said.

BioNTech is producing the vaccine for the trials in its European manufacturing facilities.

Pfizer is investing in developing its own manufacturing capacity for the vaccine, and is preparing sites in Massachusetts, Michigan, Missouri and Belgium to begin producing it.

Both companies will jointly commercialize the vaccine, if approved. (Reporting by Carl O'Donnell and Michael Erman in New York; editing by Bill Berkrot)

https://www.dailymail.co.uk/health/article-8288281/Pfizer-BioNTech-set-begin-U-S-coronavirus-vaccine-trial.html

[calendria]

 

 

An invention that really works, has a delivery system in place and could turn this virus lion into a lamb!

Hemopurifier blood dialysis filtering system using blood dialysis machines.

Show Me the Patent #!!!!       



Coronaviruses without preventive vaccines are the Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV), and the novel coronavirus SARS-CoV-2, which causes COVID-19 disease in humans.


This was a surprise, worked for Ebola maybe it would pull Coronaviruses out too!


Hemopurifier made of protein mesh material attaches to a dialysis machine - The specially designed filter is made of a protein that acts as glue for proteins found on the Ebola virus surface. Over a period of 6.5 hours, the filter extracted the virus from the blood that flows through. While most dialysis filters can pull out molecules that are less than 4 nanometers in diameter, the virus filter boasts a mesh that’s able to filter out larger viral particles that are less than 250 nanometers. That means only the virus is pulled out, and the immune cells remain in the blood, ready to fight off any remaining viral invaders.

RELATED STORIES


https://time.com/3586271/ebola-treatment-dialysis-blood/



That’s when Geiger recalled reading about a novel way of treating viruses that didn’t involve drugs. Aethlon Medical, a California-based company, was testing a way to quite literally filter viruses out of the blood of infected patients. The team had been testing their device, which attached to standard kidney dialysis machines, on hepatitis C and HIV patients in India. The German doctors, desperate to help their patient, asked to test it for Ebola.

“We had no [idea] about how much [virus] would be extracted, because this was the first patient, but I was very surprised because the drop in viral load was deeper than I expected,” says Geiger. Before the filtration began, the patient’s virus count was about 400,000 per mL blood. After the session it had dropped to 1,000 copies/mL.

What’s more, when Geiger’s team sent the filter, which was designed to safely contain the Ebola virus it had extracted, to the University of Marburg, which has a biosafety level 4 laboratory for safely handling the virus, they learned that the device had managed to trap 242 million copies of the virus.

Freed from that viral burden, the patient soon began to improve rapidly. His own immune system began fighting off the remaining virus, and he no longer needs dialysis or a ventilator. The patient is walking and waiting to be released from the hospital.

Geiger stresses that it’s not clear yet whether the Hemopurifier alone was responsible for the patient’s recovery, since he was given other experimental therapies, but the amount of virus removed from his body and his rapid recovery after the filtration suggests that it at least played a role in helping him survive his infection.

While puling viruses out of infected individuals has never been tried before, Geiger believes it will be an important strategy for treating not just Ebola but other viral infections as well, including HIV, hepatitis and even influenza. “It’s a very interesting concept. The big advantage is that the plasma is filtered, and only the virus is removed and the other plasma components like immune cells go back to the patient. That’s important because with viral infections, the patient is in a reduced immune situation.”

The device works with most standard kidney dialysis machines, so Geiger says most hospitals would have no problem using it. And his team have worked out the mechanics of setting the blood flow to the proper levels to ensure the filter works at its best. “We have all the data that could be applied at other centers and for other users of the device,” he says.





UPDATE:

The Hemopurifier® in Infectious Disease :: Aethlon Medical ...

https://www.aethlonmedical.com/the-hemopurifier

The Hemopurifier® in Infectious Disease. We’re Developing Medical Countermeasures with Broad-Spectrum Capabilities Statement regarding Aethlon’s position with respect to the potential for use of the Hemopurifier as a countermeasure against the current coronavirus SARS-CoV-2 (COVID-19) outbreak.

[JediJohnnie]

If they think they can make this vaccine mandatory, they're in for a shock...

[Drutts0643]

If they think they can make this vaccine mandatory, they're in for a shock...

Right on!!Make sure you get Satans approval first.

[singletonb]

I will be glad when the finally come up with something that definitely works with minimal side effects.

[JediJohnnie]

If they think they can make this vaccine mandatory, they're in for a shock...

Right on!!Make sure you get Satans approval first.

I don't need the Watchtower's approval, thank you. 

[ktheodos]

Encouraging to see....I read about another vaccine that has shown promise and could be released in January...I can't imagine people won't want the vaccine...I also think that more people will get flu vaccines this year

[tjshorty]

Interesting read.  Thanks for the information.

[calendria]

 

 

Here's some articles about a trial on a vaccine, how we can keep up with all the trials going on just now is a good topic to have updates posted.  I hope someone thinks of this soon!

The World Health Organization (WHO) listed eight vaccines candidates as being tested on humans in a May 15 overview here
This includes firms such as Moderna Inc (MRNA.O), Inovio (INO.O), partners Pfizer Inc (PFE.N) and BioNTech (BNTX.O) as well as China’s CanSino (6185.HK) and Sinovac (SVA.O).
 


Oxford COVID-19 vaccine begins human trial stage …

http://www.ox.ac.uk/news/2020-04-23-oxford-covid-19-vaccine-begins-human-trial-stage

https://www.reuters.com/article/us-health-coronavirus-astrazeneca-oxford-idUSKBN22Y1A4

Apr 23, 2020 · University of Oxford researchers have begun testing a COVID-19 vaccine in human volunteers in Oxford today. Around 1,110 people will take part in the trial, half receiving the vaccine and the other half (the control group) receiving a widely available meningitis vaccine

The British drugmaker has already signed up Britain and the United States as partners to mass produce the vaccine, to be ready for delivery if and when there is conclusive evidence that it both works and is safe to use.
AstraZeneca Chief Executive Pascal Soriot said last month that a first indication on efficacy would likely come in June or July.
Healthy volunteers will be randomly assigned to either receive the ChAdOx1 vaccine, also known as AZD1222, or an established meningitis vaccine.



and another trial:

https://www.theguardian.com/society/2020/may/18/first-human-trial-results-raise-hopes-for-coronavirus-vaccine

Part of a first-stage trial of 45 people run by the US company Moderna, the results are from a preliminary safety study and do not demonstrate that the treatment will work. But they will be a sign of encouragement for experts and governments desperate for a breakthrough in the battle to bring an end to the coronavirus pandemic – widely believed to be impossible without a vaccine.
Oxford University has published results of safety trials in macaque monkeys. While the vaccine prevented the monkeys from developing pneumonia, it did not block the virus from infecting the animals.

[nmbrown863]

Thats interesting! I hope they come up with a vaccine!

[Donnamarg323]

The Watchtower backs up using bible how Satan is Gods enemy and how he got many angels to join him in rebellion against the truth,and the havoc they have caused after they got ousted from heaven.

Hardly a mention of any of that with Christendom.Understand why,Satan controls Christendom,his best weapon is to make others think he doesnt exist,and he does a good job of that.

For someone who is supposed to be in hell <Satan>he certainly has been in heaven and earth more,that is of course as long as u support what bible says.

Quote from: JediJohnnie on May 18, 2020, 01:21:28 pm
If they think they can make this vaccine mandatory, they're in for a shock...
Right on!!Make sure you get Satans approval first.

I don't need the Watchtower's approval, thank you.

[ghunter]

If they find a vaccine, I pray and hope they don't make it mandatory because I don't take the flu shot.

[countrygirl12]

If they find a vaccine, I pray and hope they don't make it mandatory because I don't take the flu shot.

They can't make it mandatory. That is against your constitutional rights. I do not take the flu shot either and I won't take this. The majority of people have said they will not take it. People better wake up and see what is going on in front of them.

[minioncookies]

You no experimental and being given to those who are healthy don't sound right. You think they try it on vollunteers who have the virus to see if it actually works instead . To me it sounds like backwards thinking and since its experimental there could be side effects that could take form weeks after given just like any other experimental drugs out there vaccines are the same

[claudegrizzle]

Interesting info, but hopefully they will come up with a vaccine for those who wish to take it. We still live in a country that supposedly gives us free choice and we should be able to choose if this is right for each and every one of us.